CHIPOpt

CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research[1].

C39H47N7O9

757.83

O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC1)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)CC(C)C

Tau Protein

Room temperature