Chk1-IN-6 [CAS 2428423-77-0]

Chk1-IN-6 is a selective and orally active Chk1 inhibitor with an IC50 of 16.1 nM. Chk1-IN-6 shows antiproliferative activity of MV-4-11 cells. Chk1-IN-6 exerts effective response in the MV-4-11 xenograft mouse model. Chk1-IN-6 exhibits synergistic anticancer effect with Gemcitabine. Chk1-IN-6 can be used in the research of cancers such as acute myeloid leukemia and colorectal adenocarcinoma[1].

[2428423-77-0]

C16H18F3N7

365.36

N#CC(C=C1)=NC=C1NC2=NC=C(C(F)(F)F)C(NCCC(C)(C)N)=N2

Checkpoint Kinase (Chk)

Chk1

98.39

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature