Chlorambucyl-proline [CAS 81050-71-7]
Chlorambucyl-proline [CAS 81050-71-7]
SKU:QM-0090936
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Product Details
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Description
Chlorambucyl-proline is a chloroplatinyl amino acid derivative with inhibitory activity against bovine pulmonary vasoconstrictor enzyme. Chlorambucyl-proline reacts with the convertase in a 1:1 ratio, and the removal of its radiolabel indicates that the compound has an irreversible inhibitory effect on the enzyme activity. Chlorambucyl-proline binds to the aspartic acid or glutamic acid side chain of the enzyme by forming an ester bond, resulting in irreversible inactivation of the enzyme. The inactivation rate constant of chlororambucyl-proline increases in the pH range of 5-8, indicating that its effect on the enzyme activity is affected by the pH environment[1].
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CAS Number
[81050-71-7]
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Molecular Formula
C19H26Cl2N2O3
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Molecular Weight
401.33
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Smiles
O=C(O)[C@H]1N(C(CCCC2=CC=C(N(CCCl)CCCl)C=C2)=O)CCC1
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Target
Endogenous Metabolite
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Shipping Conditions
Room temperature
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Chlorambucyl-proline [CAS 81050-71-7]
Chlorambucyl-proline is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.