Chloroxoquinoline [CAS 23833-97-8]
Chloroxoquinoline [CAS 23833-97-8]
SKU:QM-0050490
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Product Details
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Description
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer[1].
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CAS Number
[23833-97-8]
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Molecular Formula
C9H6ClNO
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Molecular Weight
179.6
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Smiles
O=C1C=CNC2=C1C=CC(Cl)=C2
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Target
Cytochrome P450; DNA/RNA Synthesis; ROCK
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Chloroxoquinoline [CAS 23833-97-8]
Chloroxoquinoline is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.