Chlorthalidone Impurity G [CAS 16289-13-7]
Chlorthalidone Impurity G [CAS 16289-13-7]
SKU:QM-0131174-01
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Product Details
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Description
Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.
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CAS Number
[16289-13-7]
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Molecular Formula
C14H9Cl2NO2
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Molecular Weight
294.13
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Smiles
O=C1NC(O)(C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3
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Target
Carbonic Anhydrase
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Chlorthalidone Impurity G [CAS 16289-13-7]
Chlorthalidone Impurity G is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.