CHM-1 [CAS 154554-41-3]

CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity[1][2][3].

[154554-41-3]

C16H10FNO3

283.25

O=C1C=C(C2=CC=CC=C2F)NC3=C1C=C4C(OCO4)=C3

Microtubule/Tubulin

99.57

DMSO : 5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature