Cholesterol 24-hydroxylase-IN-3 [CAS 1630746-27-8]
Cholesterol 24-hydroxylase-IN-3 [CAS 1630746-27-8]
SKU:QM-0011899-01
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Product Details
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Description
Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC50 = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases[1].
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CAS Number
[1630746-27-8]
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Molecular Formula
C13H10F3N3O2
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Molecular Weight
297.23
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Smiles
O=C(C1CC1)NC2=CC(C(F)(F)F)=CC(C3=CN=CO3)=N2
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Target
Cytochrome P450
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Purity
98.74
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Solubility
DMSO : 25 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Cholesterol 24-hydroxylase-IN-3 [CAS 1630746-27-8]
Cholesterol 24-hydroxylase-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.