CIAC101

CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC50 of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides (LPS) -induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6). CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease[1].

C24H29NO4

395.49

O=C1[C@](OC2=C(OCC(C)C)C=CC3=C24)([H])[C@]54CCN(CC6CC6)[C@](C3)([H])[C@@]5(O)C=C1

Interleukin Related; NF-κB; NO Synthase; TNF Receptor; Toll-like Receptor (TLR)

IL-1; IL-6; iNOS; NF-κB; TLR4; TNFRSF5/CD40

Room temperature