Cis-BG47

Cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research[1].

C25H22N4O2S

442.53

O=C(C1=CC=C(C=C1)/N=N\C2=CC=C(C=C2)N(C)C)NC3=CC(C4=CC=CS4)=CC=C3O

HDAC; Histone Methyltransferase

HDAC1; HDAC2

98.02

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature