Cis-NVP-ADW742 [CAS 475489-15-7]

Cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742. NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells[1][2].

[475489-15-7]

C28H31N5O

453.58

NC1=C2C(N([C@H]3C[C@@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1

Apoptosis; IGF-1R; Insulin Receptor

Room temperature