CK-2-68 [CAS 1361004-87-6]

CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC50 of 40 nM[1].

[1361004-87-6]

C24H17ClF3NO2

443.85

O=C1C(C)=C(NC2=C1C=CC(Cl)=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F

Parasite

98.91

DMSO : 33.33 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice