CKI-7 [CAS 1177141-67-1]

CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1) . CKI-7 has a much weaker effect on casein kinase II and other protein kinases[1][2][3][4].

[1177141-67-1]

C11H14Cl3N3O2S

358.67

O=S(C1=CC=C(Cl)C2=C1C=NC=C2)(NCCN)=O.[H]Cl.[H]Cl

Casein Kinase; CDK; Ribosomal S6 Kinase (RSK) ; SGK

CDC; CK1; p70S6K

99.97

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, sealed storage, away from moisture)

Room Temperature

H301

H301