CL-13

CL-13 is a butyrylcholinesterase (BChE) inhibitor, with an IC50 of 1.15 μM, and a selectivity index (SI) of 9.2 for acetylcholinesterase. CL-13 shows antioxidant activity in SH-SY5Y cells (DPPH EC50 = 47.01 μM) and has the ability to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at 50 μM. CL-13 can reverse cognitive impairment caused by scopolamine without affecting the mice's motor skills[1].

C29H32N4OS

484.66

S=C(N/N=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)NC2=C(C=CC=C3)C3=NC4=CC=CC=C42

Amyloid-β; Cholinesterase (ChE)

BChE

Room temperature