CL 316243 [CAS 138908-40-4]

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors[1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate[2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence[3].

[138908-40-4]

C20H18ClNNa2O7

465.79

O=C(C1(C(O[Na])=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O[Na]

Adrenergic Receptor

β adrenergic receptor

99.98

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4.55 mg/mL (ultrasonic; warming; adjust pH to 12 with 1 M NaOH; heat to 60°C)

4°C (Powder, sealed storage, away from moisture)

Room Temperature