Cl-amidine [CAS 913723-61-2]

Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR) -16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model[1][2][3][4][5].

[913723-61-2]

C14H19ClN4O2

310.78

O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1

Apoptosis; MicroRNA; Protein Arginine Deiminase

10 mM in DMSO

Room temperature

H302-H312-H315-H319-H332-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501