CLK1-IN-3 [CAS 2922550-28-3]

CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].

[2922550-28-3]

C24H23FN6O

430.48

CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O

Autophagy; CDK; DYRK

CLK; DYRK1

98.54

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature