CLK2/3-IN-1

CLK2/3-IN-1 (Compound 7c) is an orally active CLK2/3 inhibitor (EC50: 5.07 nM and 30.03 nM, respectively) . CLK2/3-IN-1 binds to Lys193 and Lys186 of CLK2/3 via hydrogen bonds. CLK2/3-IN-1 can inhibit the proliferation of SW480 tumor cells (IC50: 163 nM) . CLK2/3-IN-1 can be used to study CLK-related tumor diseases[1].

C24H25N7O

427.5

CN1C=C(C=C(C2=CC=NC(NC(C3=CC(N4CCN(C)CC4)=NC=C3)=O)=C2)C=C5)C5=N1

CDK

Room temperature