CMC2.24 [CAS 1255639-43-0]

CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis[1][2][3].

[1255639-43-0]

C26H21NO5

427.45

O=C(NC1=CC=CC=C1)C(C(/C=C/C2=CC=C(O)C=C2)=O)C(/C=C/C3=CC=C(O)C=C3)=O

Apoptosis; MMP; Ras

MMP-1; MMP-12; MMP-13; MMP-14; MMP-2; MMP-3; MMP-7; MMP-8; MMP-9

97.48

DMSO : < 1 mg/mL

-20°C (Powder, protect from light)

Blue Ice

H302, H315, H319

H302, H315, H319