(-) -CMLD010509 [CAS 2240186-24-5]

(-) -CMLD010509 ((-) -SDS-1-021) is an isomer of CMLD010509 (SDS-1-021). CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM) -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism[1].

[2240186-24-5]

C27H26BrNO7

556.4

O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)Br)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(NOC)=O

Apoptosis; c-Myc

Room temperature