CNBCA

CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1].

C26H34O5

426.55

OC(CCCC1=C(OCCCCCCCCC)C=CC(C2=CC=C(C(O)=O)C=C2)=C1)=O

SHP2

10 mM in DMSO

Room temperature