COMT-IN-2

COMT-IN-2 (compund 9) is the potent COMT inhibitor, showing selective inhibition of brain (IC50=24 nM) and liver (IC50=81 nM) MB-COMT compared to the liver S-COMT (IC50=620 nM) isoform[1].

C13H13NO2

215.25

O=C1C=CN(C=C1O)C2=CC(C)=C(C=C2)C

COMT

Room temperature