COR628 [CAS 550310-04-8]

COR628 is a positive allosteric modulator of GABA (B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration[1].

[550310-04-8]

C16H23NO3S

309.42

O=C(OC)C1=C(SC(C)=C1CC)NC(C2CCCCC2)=O

GABA Receptor

Room temperature