COX-2-IN-31

COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM) . COX-2-IN-31 also inhibits transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity[1].

C17H16N6O4S

400.41

NC1=C(C=NN1C2=CC=C(C=C2)S(N)(=O)=O)C(N/N=C/C3=CC=C(C=C3)O)=O

COX

COX-1; COX-2

10 mM in DMSO

Room temperature