COX-2-IN-51 [CAS 3064260-49-4]

COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin.

[3064260-49-4]

C23H18F4O3S

450.45

FC1=CC=C(OC(OCCC2=CSC=C2)(C(F)(F)F)C(C3=CC=C(OC)C=C3)=C4)C4=C1

COX; NF-κB

COX-2

Room temperature