COX-2-IN-57

COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. COX-2-IN-57 reduces MyD88 expression and decreases serum levels of COX-2, PGE2, and COX-1 in Cisplatin /radiation-induced neuropathy rat model. COX-2-IN-57 demonstrates superior antinociceptive efficacy in hot plate, cold allodynia, and Randall-Selitto tests, along with hepato-/renal protection. COX-2-IN-57 can be used for the study of inflammation[1].

C34H23Cl2N3O4S

640.54

O=C(O)CC1=CC=CC=C1N(C2=C(Cl)C=CC=C2Cl)C(CSC(N3C4=CC=CC=C4)=NC5=C(C=C6C(C=CC=C6)=C5)C3=O)=O

COX; MyD88

COX-1; COX-2

Room temperature