COX-2-IN-60 [CAS 3073624-74-2]

COX-2-IN-60 is a potent, orally active, and selective  COX-2  inhibitor with an IC50 of 0.06 μM. COX-2-IN-60 exhibits ~100-fold selectivity over  COX-1 (IC50 = 5.93). COX-2-IN-60 reduces oxidative stress and neuroinflammatory cytokines, and effectively counteracts epileptogenesis. COX-2-IN-60 exhibits significant anticonvulsant effects and protects against hippocampal injury by suppressing oxidative stress (reducing MDA  and NO), pro-inflammatory signaling (reducing TNF-α and IL-6), and glial activationin in the Pilocarpine -induced seizure mouse model. COX-2-IN-60 can be used for the research on  neuroinflammatory and  epilepsy[1].

[3073624-74-2]

C17H15BrN2O4

391.22

O=C(O)COC1=CC=C(Br)C=C1/C=N/NC(CC2=CC=CC=C2)=O

COX; Interleukin Related; TNF Receptor

COX-1; COX-2

Room temperature