COX-2-IN-7

COX-2-IN-7 (compound 4a) is a potent, selective, and orally active inhibitor of COX-2 with an IC50 of 6.585 uM. COX-2-IN-7 has higher COX-2 selectivity than Celecoxib. COX-2-IN-7 shows good in vivo anti-inflammatory and low ulcerogenic activity[1].

C15H13N3O2S2

331.41

CS(=O)(C1=CC=C(C=C1)N2N=C(N=C2C3=CC=CC=C3)S)=O

COX

10 mM in DMSO

Room temperature