COX-2/NLRP3-IN-1 [CAS 3057274-61-7]

COX-2/NLRP3-IN-1 (Compound 6k) is a COX-2/NLRP3 inhibitor with a IC50 of 1.53 μM for COX-2. COX-2/NLRP3-IN-1 exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway[1].

[3057274-61-7]

C24H19Cl2N5OS

496.41

ClC1=C(NC2=CC=CC=C2CC3=NN=C4N3N=C(C5=C(OC)C=CC=C5)CS4)C(Cl)=CC=C1

COX; NF-κB; NOD-like Receptor (NLR)

COX-2

10 mM in DMSO

Room temperature