CP-346086 (dihydrate) [CAS 1262769-98-1]

CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo[1].

[1262769-98-1]

C26H26F3N5O3

513.51

O=C(C1=CC=CC=C1C2=CC=C(C(F)(F)F)C=C2)NC3=CC4=C(CN(CC5=NC=NN5)CC4)C=C3.[H]O[H].[H]O[H]

Microsomal Triglyceride Transfer Protein (MTP)

10 mM in DMSO

Room temperature