CRA-026440 [CAS 847460-34-8]

CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4, 14, 11, 15, 7, and 20 nM respectively. CRA-026440 shows antitumor and antiangiogenic activities[1]. CRA-026440 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

[847460-34-8]

C23H24N4O4

420.46

O=C(C(N1)=CC2=C1C=CC(OCCN(C)C)=C2)NCC#CC3=CC=C(C(NO)=O)C=C3

Apoptosis; HDAC

HDAC1; HDAC10; HDAC2; HDAC3; HDAC6; HDAC8

DMSO : 100 mg/mL (ultrasonic)

Room temperature