CRT0066101 [CAS 956123-34-5]

CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS -induced lung injury models, and has anticancer effects[1][2][3].

[956123-34-5]

C18H22N6O

338.41

N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1

Apoptosis; Pim; PKD

PIM2; PKD1; PKD2; PKD3

99.88

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H312, H332

H302, H312, H332