CSI86

CSI86 is a MYC-targeting PROTAC degrader with antiproliferative activity (IC50: 13-18 μM). CSI86 is composed of MYC inhibitor (red part) CSI118 TFA , E3 ligase ligand (blue part) VH032 (HY-120217), and PROTAC linker (black part) Succinic anhydride (HY-79369). The conjugate composed of E3 ligase ligand and linker is (S, R, S) -CO-C2-acid (HY-131866).

C48H50F9N7O7S

1040

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCOC4=C(C(O)=C(C=C4)C5=CC(C(F)(F)F)=NN5C)C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6)=O)=O)=O)O)=O

C-Myc; PROTACs

Room temperature