CST905 [CAS 3094183-98-6]

CST905 is a potent PROTAC degrader of BRAF-V600E with a DC50 of 18 nM. CST905 is suitable for cancer research. (Structure Note: Pink: target protein ligand ; Blue: E3 ligase ligand (HY-125845) ; Black: linker (HY-78378) ).

[3094183-98-6]

C51H58F2N10O7S2

1025.2

O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(N(CC)C)=O)=C6F)=O)C5=C4)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7

PROTACs; Raf

B-Raf

Room temperature