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SKU:QM-0143776-01
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CU-115 is a potent TLR8 antagonist (IC50=1.04 μM), and shows selective for TLR8 over TLR7 (IC50=>50 μM) . CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells[1].
[2471982-20-2]
C21H11F7INO2
569.21
O=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F
Toll-like Receptor (TLR)
TLR7; TLR8
99.63
DMSO : 100 mg/mL (ultrasonic)
-20°C, 3 years; 4°C, 2 years (Powder)
Room Temperature
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CU-115 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.