Cucurbitacin IIb [CAS 50298-90-3]

Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].

[50298-90-3]

C30H48O7

520.7

C[C@@]([C@@](CC=C1[C@@]2([H])C[C@H](O)[C@@H](O)C1(C)C)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(CCC(C)(O)C)=O)[C@@]4(C3)C

Apoptosis

99.74

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335