Cudraflavone B [CAS 19275-49-1]
Cudraflavone B [CAS 19275-49-1]
SKU:QM-0091677
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Product Details
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Description
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells[1][2].
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CAS Number
[19275-49-1]
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Molecular Formula
C25H24O6
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Molecular Weight
420.45
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Smiles
O=C1C2=C(C3=C(C=C2OC(C4=C(O)C=C(O)C=C4)=C1C/C=C(C)\C)OC(C)(C)C=C3)O
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Target
COX; ERK; NF-κB; p38 MAPK; Sirtuin; TNF Receptor
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Isoform
COX-1; COX-2; ERK; NF-κB; p38 MAPK; SIRT1; TNFRSF1A/CD120a
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Cudraflavone B [CAS 19275-49-1]
Cudraflavone B is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.