Cyclosporin A-d12

Cyclosporin A-d12 (Cyclosporine A-d12) is deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8].

C62H99D12N11O12

1214.69

C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@](C(C)C)(N(C([C@@H](N(C([C@](CC(C)C)(N(C([C@H](NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@@](NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CC)NC1=O)=O)=O)=O)(C(C)C)[H])=O)=O)C)=O)C)=O)C)[H])=O)C([2H])([2H])[2H])C([2H])(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[2H])=O)C)[H])=O)C)O

Antibiotic; Complement System; Cyclophilin; Isotope-Labeled Compounds; Molecular Glues

Room temperature