Cyclotraxin B [CAS 1203586-72-4]

Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3].

[1203586-72-4]

C48H73N13O17S3

1200.37

O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)N)C(O)=O)=O)=O)CCC(O)=O)=O)CCCCN)=O)([H])[C@H](O)C)=O)CC3=CC=C(C=C3)O)=O)=O)CCSC)=O

P38 MAPK; Trk Receptor

TrkB

99.78

H2O : 100 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)

Blue Ice