Cynaropicrin [CAS 35730-78-0]

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

[35730-78-0]

C19H22O6

346.37

C=C([C@H]1O)[C@]([C@@]2([H])C1)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@@H](OC(C(CO)=C)=O)CC2=C

MMP; NF-κB; TNF Receptor

MMP-13; NF-κB; TNFRSF5/CD40

10mM

99.79

DMSO : 100 mg/mL (ultrasonic)

-20°C (Powder, protect from light)

Blue Ice

H317

H317