CYP3A4-IN-4

CYP3A4-IN-4 (compound Δ, Λ-3), a Ru (II) Ir (III) Conjugate, is a photoactive inhibitor of the major human drug metabolizing enzyme CYP3A4. CYP3A4-IN-4 containing the [Ru (tpy) (Me2bpy) ] photocaging group showed an IC50 of 2.2 μM for inhibition of microsomal CYP3A4 under light conditions (λirr=530 nm, tirr=15 min) . CYP3A4-IN-4 shows the phototherapeutic index (PI) for of 5.4[1].

C80H61Cl3IrN11ORuS2

1656.19

O=C(CCC1=CC=[N]([Ru+2]23([N]4=C5C=CC=C4C6=CC=CC=[N]62)([N]7=C(C)C=CC=C7C8=CC=CC(C)=[N]83)[N]9=C5C=CC=C9)C=C1)NCC%10=C[N]%11=C(C%12=[N]([Ir+]%13%14(C%15=C(C%16=[N]%14C(C=CC=C%17)=C%17C=C%16)SC%18=C%15C=CC=C%18)%11C%19=C(C%20=[N]%13C(C=CC=C%21)=C%21C=C%20)SC%22=C%19C=CC=C%22)C=CC=C%12)C=C%10.[Cl-].[Cl-].[Cl-]

Cytochrome P450

CYP3

Room temperature