CYP51-IN-26

CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections[1].

C20H22F3N7O

433.43

OC(C1=CC=C(C=C1F)F)(CN2CCC(CC2)NC3=NC=C(C=N3)F)CN4N=CN=C4

Cytochrome P450; Fungal

Room temperature