Cytarabine 5’-monophosphate [CAS 7075-11-8]

Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine , catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research[1].

[7075-11-8]

C9H14N3O8P

323.2

O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C(N=C(N)C=C2)=O

DNA/RNA Synthesis; Drug Metabolite

98.04

H2O : 4.17 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501