D-01

D-01 is a dual-targeting inhibitor of HIF-1α and EZH2 (IC50: 4.86 μM and 0.99 μM respectively) . D-01 inhibits the expression of H3K27me3 protein. D-01 inhibits the migration, clone and the invasion of A549 cells, and also inhibits tube formation of HUVECs. D-01 can be used for research of lung cancer[1].

C37H43N3O8

657.75

CC1(C)OC2=CC=C(C(/C=C/C3=CC=C(OCCCN4CCOCC4)C(OCC(NCC5=C(C)C=C(C)NC5=O)=O)=C3)=O)C(O)=C2C=C1

HIF/HIF Prolyl-Hydroxylase; Histone Methyltransferase

EZH2; HIF-1α

Room temperature