D-Histidine (hydrochloride hydrate) [CAS 328526-86-9]
D-Histidine (hydrochloride hydrate) [CAS 328526-86-9]
SKU:QM-0048239-01
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Product Details
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Description
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu2+) [1][2][3].
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CAS Number
[328526-86-9]
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Molecular Formula
C6H12ClN3O3
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Molecular Weight
209.63
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Smiles
OC([C@H](N)CC1=CN=CN1)=O.Cl.O
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Target
Bacterial; Mitochondrial Metabolism
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Purity
99.46
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Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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D-Histidine (hydrochloride hydrate) [CAS 328526-86-9]
D-Histidine (hydrochloride hydrate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.