DAA

DAA is a potent autophagy inducer that exhibits antitumor efficacy and enhances anti-PD1 immunotherapy in non-small cell lung cancer (NSCLC) . DAA acts by disrupting the LIC1-RuvB-like AAA ATPase 1 interaction, which activates the GCN2-eIF2α-ATF4 integrated stress response pathway and promotes autophagic cell death. DAA can be used for NSCLC research[1].

C24H28O10

476.47

COC1=CC(O)=C(C([C@]2([C@H](OC(C(C)C)=O)[C@H](OC(C(C)C)=O)[C@](O)(C)C3)[C@@]3(O2)C4=O)=O)C4=C1

Autophagy

Room temperature