DACN (Tos, Suc-OH) [CAS 2109751-68-8]

DACN (Tos, Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity[1].

[2109751-68-8]

C18H22N2O5S

378.44

O=C(CCC(N1CC#CCN(S(=O)(C2=CC=C(C)C=C2)=O)CCC1)=O)O

ADC Linker

10 mM in DMSO

Room temperature