Danshensu [CAS 76822-21-4]

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

[76822-21-4]

C9H10O5

198.17

OC1=C(C=CC(C[C@H](C(O)=O)O)=C1)O

Apoptosis; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS) ; SARS-CoV

98.59

DMSO : < 1 mg/mL|H2O : 5 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335