Dasabuvir (sodium) [CAS 1132940-11-4]

Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively[1].

[1132940-11-4]

C26H27N3NaO5S

516.56

O=C1C=CN(C2=CC(C(C)(C)C)=C(OC)C(C3=CC=C4C=C(NS(=O)(C)=O)C=CC4=C3)=C2)C(N1)=O.[Na]

DNA/RNA Synthesis; HCV

10 mM in DMSO

Room temperature