DC10SMe [CAS 2649727-40-0]

DC10SMe is a DNA alkylator, can be used in the synthesis of antibody-drug conjugate (ADC) . DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively[1].

[2649727-40-0]

C35H29N5O4S2

647.77

O=C(C1=CC2=C(C=CC(NC(CCSSC)=O)=C2)N1)NC3=CC4=C(C=C3)NC(C(N5C(C67[C@H](C7)C5)=CC(C8=C6C=CC=C8)=O)=O)=C4

ADC Payload; DNA Alkylator/Crosslinker

Duocarmycins

10 mM in DMSO

Room temperature