DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) . DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) [1].
CAS Number
[6971-97-7]
Molecular Formula
C14H10Cl2N2
Molecular Weight
277.15
Smiles
ClC1=CC(/C=N/N=C/C2=CC=CC(Cl)=C2)=CC=C1
Target
MGluR
Isoform
MGluR5
Purity
98.81
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)